- Glycoprotein-fucosylgalactoside a-N-acetylgalactosaminyltransferase
enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC number|188.8.131.52) is an enzymethat catalyzes the chemical reaction
:UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)- [alpha-L-fucosyl- (1,2)] -D-galactose
Thus, the two substrates of this enzyme are
UDP-N-acetyl-D-galactosamineand glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, [glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)- [alpha-L-fucosyl-] , and (1,2)] -D-galactose.
This enzyme belongs to the family of
transferases, specifically those glycosyltransferases hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase. Other names in common use include A-transferase, histo-blood group A glycosyltransferase, (Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase), UDP-GalNAc:Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, blood-group substance A-dependent acetylgalactosaminyltransferase, fucosylgalactose acetylgalactosaminyltransferase, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A transferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose, and 3-N-acetyl-D-galactosaminyltransferase. This enzyme participates in 3 metabolic pathways: the lactoseries and neolactoseries of glycosphingolipidbiosynthesis, as wellas the biosynthesis of glycanstructures.
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LZ0, PDB link|1LZI, PDB link|1R7T, PDB link|1R7V, PDB link|1R7Y, PDB link|1R81, PDB link|1WSZ, PDB link|1WT0, PDB link|1WT1, PDB link|1WT2, PDB link|1WT3, PDB link|1XZ6, PDB link|1ZHJ, PDB link|1ZI1, PDB link|1ZI3, PDB link|1ZI4, PDB link|1ZI5, PDB link|1ZJO, and PDB link|2A8W.
CAS registry numberfor this enzyme class is CAS registry|9067-69-0."
Gene Ontology (GO) codes
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