Glycoprotein-fucosylgalactoside a-N-acetylgalactosaminyltransferase

In enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC number|2.4.1.40) is an enzyme that catalyzes the chemical reaction

:UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose $ightleftharpoons$ UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)- [alpha-L-fucosyl- (1,2)] -D-galactose

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, [glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)- [alpha-L-fucosyl-] , and (1,2)] -D-galactose.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase. Other names in common use include A-transferase, histo-blood group A glycosyltransferase, (Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase), UDP-GalNAc:Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, blood-group substance A-dependent acetylgalactosaminyltransferase, fucosylgalactose acetylgalactosaminyltransferase, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A transferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose, and 3-N-acetyl-D-galactosaminyltransferase. This enzyme participates in 3 metabolic pathways: the lactoseries and neolactoseries of glycosphingolipid biosynthesis, as wellas the biosynthesis of glycan structures.

tructural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LZ0, PDB link|1LZI, PDB link|1R7T, PDB link|1R7V, PDB link|1R7Y, PDB link|1R81, PDB link|1WSZ, PDB link|1WT0, PDB link|1WT1, PDB link|1WT2, PDB link|1WT3, PDB link|1XZ6, PDB link|1ZHJ, PDB link|1ZI1, PDB link|1ZI3, PDB link|1ZI4, PDB link|1ZI5, PDB link|1ZJO, and PDB link|2A8W.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9067-69-0."

Gene Ontology (GO) codes