Sulfate adenylyltransferase

In enzymology, a sulfate adenylyltransferase (EC number|2.7.7.4) is an enzyme that catalyzes the chemical reaction

:ATP + sulfate $ightleftharpoons$ diphosphate + adenylyl sulfate

Thus, the two substrates of this enzyme are ATP and sulfate, whereas its two products are diphosphate and adenylyl sulfate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:sulfate adenylyltransferase. Other names in common use include ATP-sulfurylase, adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, adenylylsulfate pyrophosphorylase, ATP sulfurylase, ATP-sulfurylase, and sulfurylase. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.

tructural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1G8F, PDB link|1G8G, PDB link|1G8H, PDB link|1I2D, PDB link|1J70, PDB link|1JEC, PDB link|1JED, PDB link|1JEE, PDB link|1JHD, PDB link|1M8P, PDB link|1R6X, PDB link|1TV6, PDB link|1V47, PDB link|1X6V, PDB link|1XJQ, PDB link|1XNJ, PDB link|1ZUN, and PDB link|2GKS.

Applications

ATP sulfurylase is one of the enzymes used in pyrosequencing.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9012-39-9."

Gene Ontology (GO) codes