Polynucleotide 5'-hydroxyl-kinase

In enzymology, a polynucleotide 5'-hydroxyl-kinase (EC number|2.7.1.78) is an enzyme that catalyzes the chemical reaction

:ATP + 5'-dephospho-DNA $ightleftharpoons$ ADP + 5'-phospho-DNA

Thus, the two substrates of this enzyme are ATP and 5'-dephospho-DNA, whereas its two products are ADP and 5'-phospho-DNA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:5'-dephosphopolynucleotide 5'-phosphotransferase. Other names in common use include ATP:5'-dephosphopolynucleotide 5'-phosphatase, PNK, polynucleotide 5'-hydroxyl kinase (phosphorylating), 5'-hydroxyl polynucleotide kinase, 5'-hydroxyl polyribonucleotide kinase, 5'-hydroxyl RNA kinase, DNA 5'-hydroxyl kinase, DNA kinase, polynucleotide kinase, and polynucleotide 5'-hydroxy-kinase.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LTQ, PDB link|1LY1, PDB link|1RC8, PDB link|1RPZ, PDB link|1RRC, PDB link|1UJX, PDB link|1YJ5, PDB link|1YJM, PDB link|2BRF, and PDB link|2IA5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37211-65-7."

Gene Ontology (GO) codes