Pantetheine-phosphate adenylyltransferase

In enzymology, a pantetheine-phosphate adenylyltransferase (EC number|2.7.7.3) is an enzyme that catalyzes the chemical reaction

:ATP + pantetheine 4'-phosphate $ightleftharpoons$ diphosphate + 3'-dephospho-CoA

Thus, the two substrates of this enzyme are ATP and pantetheine 4'-phosphate, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B6T, PDB link|1GN8, PDB link|1H1T, PDB link|1O6B, PDB link|1OD6, PDB link|1QJC, PDB link|1TFU, and PDB link|1VLH.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-99-7."

Gene Ontology (GO) codes