Homoserine kinase

In enzymology, a homoserine kinase (EC number|2.7.1.39) is an enzyme that catalyzes the chemical reaction

:ATP + L-homoserine $ightleftharpoons$ ADP + O-phospho-L-homoserine

Thus, the two substrates of this enzyme are ATP and L-homoserine, whereas its two products are ADP and O-phospho-L-homoserine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-homoserine O-phosphotransferase. Other names in common use include homoserine kinase (phosphorylating), and HSK. This enzyme participates in glycine, serine and threonine metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FWK, PDB link|1FWL, PDB link|1H72, PDB link|1H73, PDB link|1H74, and PDB link|2PPQ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-58-8."

Gene Ontology (GO) codes