Glucose-1-phosphate thymidylyltransferase

In enzymology, a glucose-1-phosphate thymidylyltransferase (EC number|2.7.7.24) is an enzyme that catalyzes the chemical reaction

:dTTP + alpha-D-glucose 1-phosphate $ightleftharpoons$ diphosphate + dTDP-glucose

Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and dTDP-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include glucose 1-phosphate thymidylyltransferase, dTDP-glucose synthase, dTDP-glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, and TDP-glucose pyrophosphorylase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

tructural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FXO, PDB link|1FZW, PDB link|1G0R, PDB link|1G1L, PDB link|1G23, PDB link|1G2V, PDB link|1G3L, PDB link|1H5R, PDB link|1H5S, PDB link|1H5T, PDB link|1IIM, PDB link|1IIN, PDB link|1LVW, PDB link|1MC3, PDB link|1MP3, PDB link|1MP4, PDB link|1MP5, PDB link|2GGO, and PDB link|2GGQ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-03-3."

Gene Ontology (GO) codes