DTMP kinase

In enzymology, a dTMP kinase (EC number|2.7.4.9) is an enzyme that catalyzes the chemical reaction

:ATP + dTMP $ightleftharpoons$ ADP + dTDP

Thus, the two substrates of this enzyme are ATP and dTMP, whereas its two products are ADP and dTDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, 40 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E2D, PDB link|1E2E, PDB link|1E2F, PDB link|1E2G, PDB link|1E2Q, PDB link|1E98, PDB link|1E99, PDB link|1E9A, PDB link|1E9B, PDB link|1E9C, PDB link|1E9D, PDB link|1E9E, PDB link|1E9F, PDB link|1G3U, PDB link|1GSI, PDB link|1GTV, PDB link|1MRN, PDB link|1MRS, PDB link|1N5I, PDB link|1N5J, PDB link|1N5K, PDB link|1N5L, PDB link|1NMX, PDB link|1NMY, PDB link|1NMZ, PDB link|1NN0, PDB link|1NN1, PDB link|1NN3, PDB link|1NN5, PDB link|1TMK, PDB link|1W2G, PDB link|1W2H, PDB link|2CCG, PDB link|2CCJ, PDB link|2CCK, PDB link|2PBR, PDB link|2TMK, PDB link|3TMK, PDB link|4TMK, and PDB link|5TMP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9014-43-1."

Gene Ontology (GO) codes