Carbamate kinase

In enzymology, a carbamate kinase (EC number|2.7.2.2) is an enzyme that catalyzes the chemical reaction

:ATP + NH₃ + CO₂ $ightleftharpoons$ ADP + carbamoyl phosphate

The 3 substrates of this enzyme are ATP, NH₃, and CO₂, whereas its two products are ADP and carbamoyl phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:carbamate phosphotransferase. Other names in common use include CKase, carbamoyl phosphokinase, and carbamyl phosphokinase. This enzyme participates in 4 metabolic pathways: purine metabolism, glutamate metabolism, arginine and proline metabolism, and nitrogen metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B7B, PDB link|1E19, and PDB link|2E9Y.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-69-1."

Gene Ontology (GO) codes