2'-phosphotransferase

2'-phosphotransferase

In enzymology, a 2'-phosphotransferase (EC number|2.7.1.160) is an enzyme that catalyzes the chemical reaction

:2'-phospho- [ligated tRNA] + NAD+ ightleftharpoons mature tRNA + ADP-ribose 1",2"-phosphate + nicotinamide + H2O

Thus, the two substrates of this enzyme are [2'-phospho- [ligated tRNA] and NAD+, whereas its 4 products are mature tRNA, ADP-ribose 1",2"-phosphate, nicotinamide, and H2O.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is 2'-phospho- [ligated tRNA] :NAD+ phosphotransferase. Other names in common use include yeast 2'-phosphotransferase, Tpt1, Tpt1p, and 2'-phospho-tRNA:NAD+ phosphotransferase.

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