Glycoside hydrolase family 1

Glycoside hydrolase family 1 is a family of glycoside hydrolases.

O-Glycosyl hydrolases EC number|3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different familiescite journal |author=Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G |title=Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue=15 |pages=7090–7094 |year=1995 |pmid=7624375 |doi=10.1073/pnas.92.15.7090] cite journal |author=Henrissat B, Davies G |title=Structures and mechanisms of glycosyl hydrolases |journal=Structure |volume=3 |issue=9 |pages=853–859 |year=1995 |pmid=8535779 |doi=10.1016/S0969-2126(01)00220-9] [ [http://www.expasy.ch/cgi-bin/lists?glycosid.txt Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.] ] . This classification is available on the CAZy(CArbohydrate-Active EnZymes) web site [ [http://www.cazy.org/ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.] ] . Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'.

Glycoside hydrolase family 1 [http://www.cazy.org/fam/GH_1.html CAZY GH_1] comprises enzymes with a number of known activities; beta-glucosidase (EC number|3.2.1.21); beta-galactosidase (EC number|3.2.1.23); 6-phospho-beta-galactosidase (EC number|3.2.1.85); 6-phospho-beta-glucosidase (EC number|3.2.1.86); lactase-phlorizin hydrolase (EC number|3.2.1.62), lactase (EC number|3.2.1.108); beta-mannosidase (EC number|3.2.1.25); myrosinase (EC number|3.2.1.147).

ubfamilies

*6-phospho-beta-galactosidase InterPro|IPR005928

Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

ee also

[http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_1 GH1 in CAZypedia]

References

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