Queuine tRNA-ribosyltransferase

In enzymology, a queuine tRNA-ribosyltransferase (EC number|2.4.2.29) is an enzyme that catalyzes the chemical reaction

: [tRNA] -guanine + queuine $ightleftharpoons$ [tRNA] -queuine + guanine

Thus, the two substrates of this enzyme are [tRNA] -guanine and queuine, whereas its two products are [tRNA] -queuine and guanine.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is [tRNA] -guanine:queuine tRNA-D-ribosyltransferase. Other names in common use include tRNA-guanine transglycosylase, guanine insertion enzyme, tRNA transglycosylase, Q-insertase, queuine transfer ribonucleate ribosyltransferase, transfer ribonucleate glycosyltransferase, tRNA guanine transglycosidase, guanine, queuine-tRNA transglycosylase, and tRNA-guanine:queuine tRNA-D-ribosyltransferase.

tructural studies

As of late 2007, 36 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EFZ, PDB link|1ENU, PDB link|1F3E, PDB link|1IQ8, PDB link|1IT7, PDB link|1IT8, PDB link|1J2B, PDB link|1K4G, PDB link|1K4H, PDB link|1N2V, PDB link|1OZM, PDB link|1OZQ, PDB link|1P0B, PDB link|1P0D, PDB link|1P0E, PDB link|1PUD, PDB link|1PXG, PDB link|1Q2R, PDB link|1Q2S, PDB link|1Q4W, PDB link|1Q63, PDB link|1Q65, PDB link|1Q66, PDB link|1R5Y, PDB link|1S38, PDB link|1S39, PDB link|1WKD, PDB link|1WKE, PDB link|1WKF, PDB link|1Y5V, PDB link|1Y5W, PDB link|1Y5X, PDB link|2ASH, PDB link|2BBF, PDB link|2QII, and PDB link|2QZR.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|72162-89-1."

Gene Ontology (GO) codes