Polypeptide N-acetylgalactosaminyltransferase

In enzymology, a polypeptide N-acetylgalactosaminyltransferase (EC number|2.4.1.41) is an enzyme that catalyzes the chemical reaction

:UDP-N-acetyl-D-galactosamine + polypeptide $ightleftharpoons$ UDP + N-acetyl-D-galactosaminyl-polypeptide

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include protein-UDP acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase, UDP-N-acetylgalactosamine:kappa-casein polypeptide, N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycoprotein, acetylgalactosaminyltransferase, glycoprotein acetylgalactosaminyltransferase, polypeptide-N-acetylgalactosamine transferase, UDP-acetylgalactosamine-glycoprotein, acetylgalactosaminyltransferase, UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetyl-alpha-D-galactosamine:polypeptide, N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-glycoprotein, N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide, N-acetylgalactosaminyltransferase, and UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and Calcium.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1XHB, PDB link|2D7I, PDB link|2D7R, PDB link|2FFU, and PDB link|2FFV.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-15-4."

Gene Ontology (GO) codes