GALNT3

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3), also known as GALNT3, is a human gene.cite web | title = Entrez Gene: GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2591| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities.cite web | title = Entrez Gene: GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2591| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bennett EP, Hassan H, Clausen H |title=cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17006–12 |year= 1996 |pmid= 8663203 |doi=
*cite journal | author=Wandall HH, Hassan H, Mirgorodskaya E, "et al." |title=Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23503–14 |year= 1997 |pmid= 9295285 |doi=
*cite journal | author=Röttger S, White J, Wandall HH, "et al." |title=Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. |journal=J. Cell. Sci. |volume=111 ( Pt 1) |issue= |pages= 45–60 |year= 1998 |pmid= 9394011 |doi=
*cite journal | author=Bennett EP, Weghuis DO, Merkx G, "et al." |title=Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. |journal=Glycobiology |volume=8 |issue= 6 |pages= 547–55 |year= 1998 |pmid= 9592121 |doi=
*cite journal | author=Mandel U, Hassan H, Therkildsen MH, "et al." |title=Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family. |journal=Glycobiology |volume=9 |issue= 1 |pages= 43–52 |year= 1999 |pmid= 9884405 |doi=
*cite journal | author=Dosaka-Akita H, Kinoshita I, Yamazaki K, "et al." |title=N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers. |journal=Br. J. Cancer |volume=87 |issue= 7 |pages= 751–5 |year= 2002 |pmid= 12232759 |doi= 10.1038/sj.bjc.6600536
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Argüeso P, Tisdale A, Mandel U, "et al." |title=The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 1 |pages= 86–92 |year= 2003 |pmid= 12506059 |doi=
*cite journal | author=Onitsuka K, Shibao K, Nakayama Y, "et al." |title=Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma. |journal=Cancer Sci. |volume=94 |issue= 1 |pages= 32–6 |year= 2003 |pmid= 12708471 |doi=
*cite journal | author=Yamamoto S, Nakamori S, Tsujie M, "et al." |title=Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas. |journal=Pathobiology |volume=71 |issue= 1 |pages= 12–8 |year= 2004 |pmid= 14555840 |doi= 10.1159/000072957
*cite journal | author=Gu C, Oyama T, Osaki T, "et al." |title=Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence. |journal=Br. J. Cancer |volume=90 |issue= 2 |pages= 436–42 |year= 2004 |pmid= 14735190 |doi= 10.1038/sj.bjc.6601531
*cite journal | author=Miyahara N, Shoda J, Kawamoto T, "et al." |title=Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 2090–9 |year= 2004 |pmid= 15041730 |doi=
*cite journal | author=Topaz O, Shurman DL, Bergman R, "et al." |title=Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 579–81 |year= 2004 |pmid= 15133511 |doi= 10.1038/ng1358
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ishikawa M, Kitayama J, Kohno K, Nagawa H |title=The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus. |journal=Pathobiology |volume=72 |issue= 3 |pages= 139–45 |year= 2005 |pmid= 15860931 |doi= 10.1159/000084117
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Kato K, Jeanneau C, Tarp MA, "et al." |title=Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. |journal=J. Biol. Chem. |volume=281 |issue= 27 |pages= 18370–7 |year= 2006 |pmid= 16638743 |doi= 10.1074/jbc.M602469200
*cite journal | author=Ichikawa S, Imel EA, Sorenson AH, "et al." |title=Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 11 |pages= 4472–5 |year= 2007 |pmid= 16940445 |doi= 10.1210/jc.2006-1247
*cite journal | author=Barbieri AM, Filopanti M, Bua G, Beck-Peccoz P |title=Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis. |journal=J. Hum. Genet. |volume=52 |issue= 5 |pages= 464–8 |year= 2007 |pmid= 17351710 |doi= 10.1007/s10038-007-0126-5
*cite journal | author=Inoue T, Eguchi T, Oda Y, "et al." |title=Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-. |journal=Mod. Pathol. |volume=20 |issue= 2 |pages= 267–76 |year= 2007 |pmid= 17361208 |doi= 10.1038/modpathol.3800700

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