- Lactosylceramide alpha-2,3-sialyltransferase
In
enzymology , a lactosylceramide alpha-2,3-sialyltransferase (EC number|2.4.99.9) is anenzyme that catalyzes thechemical reaction :CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide
Thus, the two substrates of this enzyme are
CMP-N-acetylneuraminate andbeta-D-galactosyl-1,4-beta-D-glucosylceramide , whereas its 3 products are CMP,alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D- , andglucosylceramide .This enzyme belongs to the family of
transferase s, specifically thoseglycosyltransferase s that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3-, sialyltransferase, CMP-acetylneuraminate-lactosylceramide-sialyltransferase, CMP-acetylneuraminic acid:lactosylceramide sialyltransferase, CMP-sialic acid:lactosylceramide-sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide, sialyltransferase, ganglioside GM3 synthetase, GM3 synthase, GM3 synthetase, and SAT 1. This enzyme participates inglycosphingolipid biosynthesis - ganglioseries andglycan structures - biosynthesis 2 .tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2EX0 and PDB link|2EX1.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|125752-90-1."Gene Ontology (GO) codes
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