Glycoprotein 2-beta-D-xylosyltransferase

In enzymology, a glycoprotein 2-beta-D-xylosyltransferase (EC number|2.4.2.38) is an enzyme that catalyzes the chemical reaction

:UDP-D-xylose + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine $ightleftharpoons$ UDP + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] - [beta-D- xylosyl-(1->2)] -beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl}asparagine

The 5 substrates of this enzyme are UDP-D-xylose, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine, whereas its 5 products are UDP, [N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-] , [acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] - [beta-D-] , xylosyl-(1->2)] -beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-, and (1->4)-N-acetyl-beta-D-glucosaminyl}asparagine.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 2-beta-D-xylosyltransferase. Other names in common use include beta1,2-xylosyltransferase, UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose, of, 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)- [N-, acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)] -beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine) 2-beta-D-xylosyltransferase. This enzyme participates in glycan structures - biosynthesis 1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|141256-56-6."

Gene Ontology (GO) codes