- Dolichyl-diphosphooligosaccharide-protein glycotransferase
In
enzymology , a dolichyl-diphosphooligosaccharide-protein glycotransferase (EC number|2.4.1.119) is anenzyme that catalyzes thechemical reaction :dolichyl diphosphooligosaccharide + protein L-asparagine dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine
Thus, the two substrates of this enzyme are
dolichyl diphosphooligosaccharide andprotein L-asparagine , whereas its 3 products aredolichyl diphosphate ,glycoprotein with the oligosaccharide chain attached by N-glycosyl , andlinkage to protein L-asparagine .This enzyme belongs to the family of
glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase. Other names in common use include dolichyldiphosphooligosaccharide-protein glycosyltransferase, asparagine N-glycosyltransferase, dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase, dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase, oligomannosyltransferase, oligosaccharide transferase, dolichyldiphosphoryloligosaccharide-protein, and oligosaccharyltransferase. This enzyme participates inn-glycan biosynthesis andglycan structures - biosynthesis 1 .tructural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1RKL.
References
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External links
::"The
CAS registry number for this enzyme class is CAS registry|75302-32-8."Gene Ontology (GO) codes
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