Dolichyl-diphosphooligosaccharide-protein glycotransferase

Dolichyl-diphosphooligosaccharide-protein glycotransferase

In enzymology, a dolichyl-diphosphooligosaccharide-protein glycotransferase (EC number|2.4.1.119) is an enzyme that catalyzes the chemical reaction

:dolichyl diphosphooligosaccharide + protein L-asparagine ightleftharpoons dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine

Thus, the two substrates of this enzyme are dolichyl diphosphooligosaccharide and protein L-asparagine, whereas its 3 products are dolichyl diphosphate, glycoprotein with the oligosaccharide chain attached by N-glycosyl, and linkage to protein L-asparagine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase. Other names in common use include dolichyldiphosphooligosaccharide-protein glycosyltransferase, asparagine N-glycosyltransferase, dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase, dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase, oligomannosyltransferase, oligosaccharide transferase, dolichyldiphosphoryloligosaccharide-protein, and oligosaccharyltransferase. This enzyme participates in n-glycan biosynthesis and glycan structures - biosynthesis 1.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1RKL.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|75302-32-8."

Gene Ontology (GO) codes


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