Diglucosyl diacylglycerol synthase

Diglucosyl diacylglycerol synthase
diglucosyl diacylglycerol synthase
Identifiers
EC number 2.4.1.208
CAS number 168680-19-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diglucosyl diacylglycerol synthase (EC 2.4.1.208) is an enzyme that catalyzes the chemical reaction

UDP-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol \rightleftharpoons 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D- glucopyranosyl)sn-glycerol + UDP

Thus, the two substrates of this enzyme are UDP-glucose and 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol, whereas its 2 products are 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1-2)-O-alpha-D-glucopyranosyl)sn-glycerol, and UDP.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase. Other names in common use include monoglucosyl diacylglycerol (1->2) glucosyltransferase, MGlcDAG (1->2) glucosyltransferase, and DGlcDAG synthase. It employs one cofactor, magnesium.

References

  • Karlsson OP, Rytomaa M, Dahlqvist A, Kinnunen PK, Wieslander A (1996). "Correlation between bilayer lipid dynamics and activity of the diglucosyldiacylglycerol synthase from Acholeplasma laidlawii membranes". Biochemistry. 35 (31): 10094–102. doi:10.1021/bi9602876. PMID 8756472. 
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