Anthranilate phosphoribosyltransferase

In enzymology, an anthranilate phosphoribosyltransferase (EC number|2.4.2.18) is an enzyme that catalyzes the chemical reaction

:N-(5-phospho-D-ribosyl)-anthranilate + diphosphate $ightleftharpoons$ anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate

Thus, the two substrates of this enzyme are N-(5-phospho-D-ribosyl)-anthranilate and diphosphate, whereas its two products are anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include phosphoribosyl-anthranilate pyrophosphorylase, PRT, anthranilate 5-phosphoribosylpyrophosphate, phosphoribosyltransferase, anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase, phosphoribosylanthranilate pyrophosphorylase, phosphoribosylanthranilate transferase, and anthranilate-PP-ribose-P phosphoribosyltransferase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general.

tructural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GXB, PDB link|1KGZ, PDB link|1KHD, PDB link|1O17, PDB link|1V8G, PDB link|1VQU, PDB link|1ZVW, PDB link|1ZXY, PDB link|1ZYK, PDB link|2BPQ, PDB link|2ELC, and PDB link|2GVQ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9059-35-2."

Gene Ontology (GO) codes