Adenosyl-fluoride synthase

In enzymology, an adenosyl-fluoride synthase (EC number|2.5.1.63) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + fluoride $ightleftharpoons$ 5'-deoxy-5'-fluoroadenosine + L-methionine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and fluoride, whereas its two products are 5'-deoxy-5'-fluoroadenosine and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:fluoride adenosyltransferase. This enzyme is also called fluorinase.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RQP, PDB link|1RQR, PDB link|2C2W, PDB link|2C4T, PDB link|2C4U, PDB link|2C5B, PDB link|2C5H, PDB link|2CBX, and PDB link|2CC2.

References

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