3-deoxy-8-phosphooctulonate synthase

In enzymology, a 3-deoxy-8-phosphooctulonate synthase (EC number|2.5.1.55) is an enzyme that catalyzes the chemical reaction

:phosphoenolpyruvate + D-arabinose 5-phosphate + H₂O $ightleftharpoons$ 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate

The 3 substrates of this enzyme are phosphoenolpyruvate, D-arabinose 5-phosphate, and H₂O, whereas its two products are 2-dehydro-3-deoxy-D-octonate 8-phosphate and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming). Other names in common use include 2-dehydro-3-deoxy-D-octonate-8-phosphate, D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphooctonate aldolase, 2-keto-3-deoxy-8-phosphooctonic synthetase, 3-deoxy-D-manno-octulosonate-8-phosphate synthase, 3-deoxy-D-mannooctulosonate-8-phosphate synthetase, 3-deoxyoctulosonic 8-phosphate synthetase, KDOP synthase, and phospho-2-keto-3-deoxyoctonate aldolase. This enzyme participates in lipopolysaccharide biosynthesis.

tructural studies

As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1O60, PDB link|1PHQ, PDB link|1PHW, PDB link|1PL9, PDB link|1Q3N, PDB link|1T8X, PDB link|1T96, PDB link|1T99, PDB link|1X6U, PDB link|1X8F, PDB link|1ZHA, PDB link|1ZJI, PDB link|2A21, PDB link|2A2I, PDB link|2EF9, PDB link|2NWR, PDB link|2NWS, PDB link|2NX1, PDB link|2NX3, PDB link|2NXG, PDB link|2NXH, and PDB link|2NXI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-96-4."

Gene Ontology (GO) codes