3-deoxy-7-phosphoheptulonate synthase

In enzymology, a 3-deoxy-7-phosphoheptulonate synthase (EC number|2.5.1.54) is an enzyme that catalyzes the chemical reaction

:phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O $ightleftharpoons$ 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

The 3 substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H₂O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming). Other names in common use include 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate, lyase (pyruvate-phosphorylating), 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate, D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, and phospho-2-oxo-3-deoxyheptonate aldolase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, cadmium.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RZM, PDB link|1VR6, PDB link|1VS1, and PDB link|2B7O.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-94-2."

Gene Ontology (GO) codes