Glutaminyl-peptide cyclotransferase

In enzymology, a glutaminyl-peptide cyclotransferase (EC number|2.3.2.5) is an enzyme that catalyzes the chemical reaction

:L-glutaminyl-peptide $ightleftharpoons$ 5-oxoprolyl-peptide + NH₃

Hence, this enzyme has one substrate, L-glutaminyl-peptide, and two products, 5-oxoprolyl-peptide and NH₃.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing). Other names in common use include glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, and glutaminyl-transfer ribonucleate cyclotransferase.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2AFM, PDB link|2AFO, PDB link|2AFS, PDB link|2AFU, PDB link|2AFW, PDB link|2AFX, PDB link|2AFZ, and PDB link|2IWA.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37257-21-9."

Gene Ontology (GO) codes