- QPCT
Glutaminyl-peptide cyclotransferase (glutaminyl cyclase), also known as QPCT, is a human
gene .cite web | title = Entrez Gene: QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25797| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.cite web | title = Entrez Gene: QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25797| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Busby WH, Quackenbush GE, Humm J, "et al." |title=An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8532–6 |year= 1987 |pmid= 3597387 |doi=
*cite journal | author=Song I, Chuang CZ, Bateman RC |title=Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. |journal=J. Mol. Endocrinol. |volume=13 |issue= 1 |pages= 77–86 |year= 1995 |pmid= 7999256 |doi=
*cite journal | author=Bateman RC, Temple JS, Misquitta SA, Booth RE |title=Evidence for essential histidines in human pituitary glutaminyl cyclase. |journal=Biochemistry |volume=40 |issue= 37 |pages= 11246–50 |year= 2001 |pmid= 11551224 |doi=
*cite journal | author=Schilling S, Hoffmann T, Rosche F, "et al." |title=Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity. |journal=Biochemistry |volume=41 |issue= 35 |pages= 10849–57 |year= 2002 |pmid= 12196024 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Schilling S, Niestroj AJ, Rahfeld JU, "et al." |title=Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49773–9 |year= 2004 |pmid= 14522962 |doi= 10.1074/jbc.M309077200
*cite journal | author=Booth RE, Misquitta SA, Bateman RC |title=Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification. |journal=Protein Expr. Purif. |volume=32 |issue= 1 |pages= 141–6 |year= 2004 |pmid= 14680951 |doi= 10.1016/S1046-5928(03)00226-2
*cite journal | author=Ezura Y, Kajita M, Ishida R, "et al." |title=Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. |journal=J. Bone Miner. Res. |volume=19 |issue= 8 |pages= 1296–301 |year= 2005 |pmid= 15231017 |doi= 10.1359/JBMR.040324
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huang KF, Liu YL, Cheng WJ, "et al." |title=Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13117–22 |year= 2005 |pmid= 16135565 |doi= 10.1073/pnas.0504184102
*cite journal | author=Huang QY, Kung AW |title=The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. |journal=J. Hum. Genet. |volume=52 |issue= 9 |pages= 757–62 |year= 2007 |pmid= 17687619 |doi= 10.1007/s10038-007-0178-6PBB_Controls
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