D-glutamyltransferase

D-glutamyltransferase
Identifiers
EC number	2.3.2.1
CAS number	9030-02-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a D-glutamyltransferase (EC 2.3.2.1) is an enzyme that catalyzes the chemical reaction

L(or D)-glutamine + D-glutamyl-peptide $\rightleftharpoons$ NH₃ + 5-glutamyl-D-glutamyl-peptide

The 3 substrates of this enzyme are L-glutamine, D-glutamine, and D-glutamyl-peptide, whereas its two products are NH₃ and 5-glutamyl-D-glutamyl-peptide.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutamine:D-glutamyl-peptide 5-glutamyltransferase. Other names in common use include D-glutamyl transpeptidase, and D-gamma-glutamyl transpeptidase. This enzyme participates in d-glutamine and d-glutamate metabolism.

References

• Williams WJ, Litwin J and Thorne CB (1955). "Further studies on the biosynthesis of gamma-glutamyl peptides by transfer reactions". J. Biol. Chem. 212: 427–438. 

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