(acyl-carrier-protein) S-malonyltransferase

(acyl-carrier-protein) S-malonyltransferase

In enzymology, a [acyl-carrier-protein] S-malonyltransferase (EC number|2.3.1.39) is an enzyme that catalyzes the chemical reaction

:malonyl-CoA + [acyl-carrier-protein] ightleftharpoons CoA + malonyl- [acyl-carrier-protein]

Thus, the two substrates of this enzyme are malonyl-CoA and [acyl-carrier-protein] , whereas its two products are CoA and [malonyl- [acyl-carrier-protein] .

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA: [acyl-carrier-protein] S-malonyltransferase. Other names in common use include malonyl coenzyme A-acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA-acyl carrier protein transacylase, [acyl carrier protein] malonyltransferase, MAT, FabD, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:ACP transacylase, MCAT, and malonyl-CoA:AcpM transacylase. This enzyme participates in fatty acid biosynthesis.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1NM2, PDB link|2CUY, PDB link|2G1H, PDB link|2G2O, PDB link|2G2Y, PDB link|2G2Z, PDB link|2H1Y, PDB link|2PFF, PDB link|2QC3, and PDB link|2QJ3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37257-17-3."

Gene Ontology (GO) codes


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