Acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase

In enzymology, an acyl- [acyl-carrier-protein] -UDP-N-acetylglucosamine O-acyltransferase (EC number|2.3.1.129) is an enzyme that catalyzes the chemical reaction

:(R)-3-hydroxytetradecanoyl- [acyl-carrier-protein] + UDP-N-acetylglucosamine $ightleftharpoons$ [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine

Thus, the two substrates of this enzyme are (R)-3-hydroxytetradecanoyl-acyl-carrier-protein and UDP-N-acetylglucosamine, whereas its two products are acyl-carrier-protein and UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (R)-3-hydroxytetradecanoyl- [acyl-carrier-protein] :UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase. Other names in common use include UDP-N-acetylglucosamine acyltransferase and uridine diphosphoacetylglucosamine acyltransferase. This enzyme participates in lipopolysaccharide biosynthesis.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1J2Z, PDB link|1LXA, PDB link|2AQ9, PDB link|2JF2, PDB link|2JF3, PDB link|2QIA, and PDB link|2QIV.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|105843-69-4."

Gene Ontology (GO) codes