Command neuron

A command neuron is a single neuron (or small set of neurons) whose stimulation results in the evocation of an endogenous, specific, naturally occurring behavior pattern (Carew, 2000). Command neurons act as neural decision making cells; push buttons that can trigger a complete, coordinated behavioral act and are often the sole determinant of whether an action is performed or not. Command neurons receive a convergence of integrative and sensory input and output to a multifarious group of pattern generating efferent cells. Stimulation of the command neuron triggers a lower level central pattern generator whose motorneurons and interneurons produce a particular fixed action pattern.

History

The term command neuron first appeared in a 1964 paper "Interneurons Commanding Swimmeret Movements in the Crayfish" by CAG Wiersma and K Ikeda in volume 12 of Comparative Biochemistry and Physiology vol 12 on pp 509–525. Wiersma and Ikeda used the term to describe how a single action potential in any of the four giant fibers that run along the dorsal margin of the crayfish nerve cord caused the crayfish to execute a tail-flip escape response. This concept came to epitomize the general neurobiological principle that complex information can be encoded on the level of individual neurons. Soon, researchers were finding command neurons in multiple invertebrate and vertebrate species, including: teleosts, crickets, cockroaches, and lobsters.

Criticism

In 1978, Kupfermann and Weiss' "The Command Neuron Concept" proposed a more rigorous definition of the command neuron than had previously been used. They suggested that for any neuron to qualify as a command neuron, its activity had to be both necessary and sufficient for the initiation of the behavior it was purported to command. This article initiated a torrent of tumultuous debate about which neurons, if any, could fit the new, more rigorous definition proposed by Kupfermann and Weiss.

Modern view

Many believe that the command neuron concept needs to be reworked in light of the subtleties uncovered by Kupfermann and Weiss' careful methodology. Even the Mauthner cell, an archetypal command cell, has been criticized as being neither necessary nor sufficient for the initiation of the C-start response it supposedly governs. Command decisions are increasingly seen as being governed by networks of interacting and redundant cells, not simply by single neurons. Critics believe that the less restrictive category of "command-like" neurons would repair the flaws in the overly strict Kupfermann and Weiss definition while more accurately classifying the role of single neurons in command decisions.

Despite Kupfermann and Weiss' scathing critique of the loose fashion with which the command neuron concept was being used in the late 1970s and the resultant abandonment of the concept by some, the command neuron concept is still extant in the most current neurobiological literature. Some accept the revisionist "command-like" neuron concept--believing that no neurons exist which can satisfy the strictures outlined in "The Command Neuron Concept". Others cling to use of the original command neuron concept as useful, rejecting the Kupfermann and Weiss strictures, and using less stringent definitions of the term (. Most seem to believe that there is a spectrum of pre-motor command organization: from parallel distributed networks on the one end, to command neurons on the other (Edwards et al. 1999)

See also

• Neuroethology

References

• Carew, T. 2000. Behavioral Neurobiology. Sinauer. Sunderland MA.

• Eaton R.C., DiDomenico R. 1985. Command and the neural causation of behavior: a theoretical analysis of the necessity and sufficiency paradigm. Brain Behav Evol. 27(2-4):132-64.

• Edwards, D. H., Heitler, W. J. & Krasne, F. B. 1999. Fifty years of command neurons: the neurobiology of escape behavior in the crayfish. Trends Neurosci. 22, 153–161.

• Hediwg, B. 2000. Control of Cricket Stridulation by a Command Neuron: Efficacy Depends on the Behavioral State. J Neurophysiol 83: 712-722.

• Korn, H., and Faber, D.S. 2005. The Mauthner Cell half a century later: a neurobiological model for decision-making? Neuron. 47, 13-28.

• Kupfermann, I. and Weiss, K. R. 1978. The command neuron concept. Behav. Brain Sci. 1: 3–39

• Reichert, H., and Wine, J. J. 1983. Coordination of lateral giant and non-giant systems in crayfish escape behaviour. Journal of Comparative Physiology. A. 153: 3-15.

• Roberts, A., Krasne, F. B., Hagiwara, G., Wme, J. J., and Krarner, A. P. 1982. Segmental giant: Evidence for a driver neuron interposed between command and motor neurons in the crayfish escape system. Journal of Neurophysiology 47: 761-781.

• Wiersma, C.A.G. and Ikeda, K. 1964. Interneurons commanding swimmeret movements in the crayfish, Procambarus clarkii (Girard) Comparative Biochemistry and Physiology. 12: 509-525

• Wine, J. J. 1984. The structural basis of an innate behavioural pattern. Journal of Experimental Biology 112: 283-319.

External links

• Mauthner Neuron
• Kupfermann and Weiss commentary on their seminal article
• Another definition of the command neuron