Hydroxyisourate hydrolase

In enzymology, a hydroxyisourate hydrolase (EC number|3.5.2.17) is an enzyme that catalyzes the chemical reaction

:5-hydroxyisourate + H₂O $$ightleftharpoons 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate

Thus, the two substrates of this enzyme are 5-hydroxyisourate and H₂O, whereas its product is 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 5-hydroxyisourate amidohydrolase. Other names in common use include HIUHase, and 5-hydroxyisourate hydrolase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2H1X and PDB link|2H6U.

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