Hydroxyisourate hydrolase
- Hydroxyisourate hydrolase
In enzymology, a hydroxyisourate hydrolase (EC number|3.5.2.17) is an enzyme that catalyzes the chemical reaction
:5-hydroxyisourate + H2O 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
Thus, the two substrates of this enzyme are 5-hydroxyisourate and H2O, whereas its product is 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 5-hydroxyisourate amidohydrolase. Other names in common use include HIUHase, and 5-hydroxyisourate hydrolase. This enzyme participates in purine metabolism.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2H1X and PDB link|2H6U.
References
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External links
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2010.
Look at other dictionaries:
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EC 3.5 — Le groupe EC3.5 rassemble des enzymes appartenant à la famille des hydrolases. Elles ont pour particularité de catalyser des réactions d hydrolyse dans des molécules possédant un carbone et un azote liés par liaison simple, double ou triple. À la … Wikipédia en Français
Семейство GH1 — гликозил гидролаз Обозначения в базах данных Pfam … Википедия
