Glucosamine-6-phosphate deaminase

Glucosamine-6-phosphate deaminase

In enzymology, a glucosamine-6-phosphate deaminase (EC number|3.5.99.6) is an enzyme that catalyzes the chemical reaction

:D-glucosamine 6-phosphate + H2O ightleftharpoons D-fructose 6-phosphate + NH3

Thus, the two substrates of this enzyme are D-glucosamine 6-phosphate and H2O, whereas its two products are D-fructose 6-phosphate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing). Other names in common use include glucosaminephosphate isomerase, glucosamine-6-phosphate isomerase, phosphoglucosaminisomerase, glucosamine phosphate deaminase, aminodeoxyglucosephosphate isomerase, and phosphoglucosamine isomerase. This enzyme participates in aminosugars metabolism. This enzyme has at least one effector, N-Acetyl-D-glucosamine 6-phosphate.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1J5X, PDB link|1JT9, PDB link|1NE7, PDB link|2BKV, and PDB link|2BKX.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9013-10-9."

Gene Ontology (GO) codes


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