Citrullinase

Citrullinase
citrullinase
Identifiers
EC number 3.5.1.20
CAS number 59088-17-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a citrullinase (EC 3.5.1.20) is an enzyme that catalyzes the chemical reaction

L-citrulline + H2O \rightleftharpoons L-ornithine + CO2 + NH3

Thus, the two substrates of this enzyme are L-citrulline and H2O, whereas its 3 products are L-ornithine, CO2, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-citrulline N5-carbamoyldihydrolase. Other names in common use include citrulline ureidase, citrulline hydrolase, and L-citrulline 5-N-carbamoyldihydrolase.

References

  • Hill DL, Chambers P (1967). "The biosynthesis of proline by Tetrahymena pyriformis". Biochim. Biophys. Acta. 148 (2): 435–47. PMID 6075416.