Chenodeoxycholoyltaurine hydrolase

Chenodeoxycholoyltaurine hydrolase
chenodeoxycholoyltaurine hydrolase
Identifiers
EC number 3.5.1.74
CAS number 125752-75-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a chenodeoxycholoyltaurine hydrolase (EC 3.5.1.74) is an enzyme that catalyzes the chemical reaction

chenodeoxycholoyltaurine + H2O \rightleftharpoons chenodeoxycholate + taurine

Thus, the two substrates of this enzyme are chenodeoxycholoyltaurine and H2O, whereas its two products are chenodeoxycholate and taurine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is chenodeoxycholoyltaurine amidohydrolase. This enzyme participates in bile acid biosynthesis.

References

  • Kawamoto K, Horibe I, Uchida K (Tokyo). "Purification and characterization of a new hydrolase for conjugated bile acids, chenodeoxycholyltaurine hydrolase, from Bacteroides vulgatus". J. Biochem. (6): 1049–53. PMID 2628421. 
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