In enzymology, an aminoacylase (EC number| is an enzyme that catalyzes the chemical reaction

:an N-acyl-L-amino acid + H2O ightleftharpoons a carboxylate + an L-amino acid

Thus, the two substrates of this enzyme are N-acyl-L-amino acid and H2O, whereas its two products are carboxylate and L-amino acid.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acyl-L-amino-acid amidohydrolase. Other names in common use include dehydropeptidase II, histozyme, hippuricase, benzamidase, acylase I, hippurase, amido acid deacylase, L-aminoacylase, acylase, aminoacylase I, L-amino-acid acylase, alpha-N-acylaminoacid hydrolase, long acyl amidoacylase, and short acyl amidoacylase. This enzyme participates in urea cycle and metabolism of amino groups.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Q7L and PDB link|1YSJ.



External links

::"The CAS registry number for this enzyme class is CAS registry|9012-37-7."

Gene Ontology (GO) codes

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