Ganglion type nicotinic receptor
- Ganglion type nicotinic receptor
The ganglion type nicotinic receptor is a type of nicotinic acetylcholine receptor, consisting of the subunit combination (α1)2(β4)3[ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138. ] .]It is located in the autonomic ganglia, where activation yields EPSP, mainly by increased Na+ and K+ permeability.
Agonists
Nicotinic agonists for this receptor include:
*acetylcholine
*carbachol
*nicotine
*epibatidine
*dimethylphenylpiperazinium
Antagonists
*α-bungarotoxin [ [http://www.neurosci.pharm.utoledo.edu/MBC3320/nicotinic.htm Neurosci.pharm - MBC 3320 Acetylcholine] ] ]
*mecamylamine
*trimetaphan
*18-Methoxycoronaridine
*Bupropion
*Dextromethorphan
*MethadoneReferences
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