Lysophospholipase

Lysophospholipase

In enzymology, a lysophospholipase (EC number|3.1.1.5) is an enzyme that catalyzes the chemical reaction

:2-lysophosphatidylcholine + H2O ightleftharpoons glycerophosphocholine + a carboxylate

Thus, the two substrates of this enzyme are 2-lysophosphatidylcholine and H2O, whereas its two products are glycerophosphocholine and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 2-lysophosphatidylcholine acylhydrolase. Other names in common use include lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, and NTE-lysophospholipase. This enzyme participates in glycerophospholipid metabolism.

tructural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1G86, PDB link|1HDK, PDB link|1IVN, PDB link|1J00, PDB link|1JRL, PDB link|1LCL, PDB link|1QKQ, PDB link|1U8U, PDB link|1V2G, PDB link|2G07, PDB link|2G08, PDB link|2G09, and PDB link|2G0A.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9001-85-8."

Gene Ontology (GO) codes


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