Nickel-transporting ATPase

nickel-transporting ATPase
Identifiers
EC number	3.6.3.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nickel-transporting ATPase (EC 3.6.3.24) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + Ni₂+out $\rightleftharpoons$ ADP + phosphate + Ni₂+in

The 3 substrates of this enzyme are ATP, H₂O, and Ni2+, whereas its 3 products are ADP, phosphate, and Ni2+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (nickel-importing).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ZLQ and 2NOO.

References

• Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 (4): 271–8. doi:10.1016/0923-2508(96)81050-3. PMID 7569321. 
• Hendricks JK, Mobley HL (1997). "Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity". J. Bacteriol. 179 (18): 5892–902. PMC 179482. PMID 9294450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=179482. 
• Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. PMID 9889977. 
• Griffiths JK and Sansom CE. The Transporter Factsbook, Academic Press, San Diego, 1998. 

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