Monosaccharide-transporting ATPase

monosaccharide-transporting ATPase
Identifiers
EC number	3.6.3.17
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a monosaccharide-transporting ATPase (EC 3.6.3.17) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + monosaccharideout $\rightleftharpoons$ ADP + phosphate + monosaccharidein

The 3 substrates of this enzyme are ATP, H₂O, and monosaccharide, whereas its 3 products are ADP, phosphate, and monosaccharide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (monosaccharide-importing). This enzyme participates in abc transporters - general.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GX6.

References

• Higgins CF (1992). "ABC transporters: from microorganisms to man". Annu. Rev. Cell. Biol. 8: 67–113. doi:10.1146/annurev.cb.08.110192.000435. PMID 1282354. 
• Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 (4): 271–8. doi:10.1016/0923-2508(96)81050-3. PMID 7569321. 
• Kemner JM, Liang X, Nester EW (1997). "The Agrobacterium tumefaciens virulence gene chvE is part of a putative ABC-type sugar transport operon". J. Bacteriol. 179 (7): 2452–8. PMC 178989. PMID 9079938. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=178989. 
• Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol.. Advances in Microbial Physiology 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. ISBN 9780120277407. PMID 9889977. 
• Song S, Park C (1998). "Utilization of D-ribose through D-xylose transporter". FEMS. Microbiol. Lett. 163 (2): 255–61. PMID 9673030. 
• Griffiths JK and Sansom CE. The Transporter Factsbook, Academic Press, San Diego, 1998. 

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