Microtubule-severing ATPase

microtubule-severing ATPase
Identifiers
EC number	3.6.4.3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a microtubule-severing ATPase (EC 3.6.4.3) is an enzyme that catalyzes the chemical reaction

ATP + H₂O $\rightleftharpoons$ ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing).

References

• McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885. 
• Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.6.4 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР El Paso County, Jefferson Territory Mammotome Look at other dictionaries: KATNA1 — Katanin p60 (ATPase containing) subunit A 1, also known as KATNA1, is a human gene.cite web | title = Entrez Gene: KATNA1 katanin p60 (ATPase containing) subunit A 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia KATNB1 — Katanin p80 (WD repeat containing) subunit B 1, also known as KATNB1, is a human gene.cite web | title = Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView …   Wikipedia List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français Katanin — is a microtubule severing AAA protein. It is named after the Japanese sword, katana. Katanin is a heterodimeric protein first discovered in sea urchins. It contains a 60 kDa ATPase subunit, which functions to sever microtubules. This subunit… …   Wikipedia Spastin — The human gene SPAST codes for the microtubule severing protein of the same name, commonly known as spastin [cite journal | author = Roll Mecak A, Vale RD | title = Structural basis of microtubule severing by the hereditary spastic paraplegia… …   Wikipedia AAA proteins — Pfam box Symbol = AAA Name = ATPases associated with diverse cellular activities (AAA) width = caption = Pfam= PF00004 InterPro= IPR003959 SMART= PROSITE= PDOC00572 SCOP = 1nsf TCDB = OPM family= OPM protein= PDB=PDB3|1jbkA:201 286 PDB3|1qvrC:193 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”