P2RY5

Purinergic receptor P2Y, G-protein coupled, 5, also known as P2RY5, is a human gene.cite web | title = Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10161| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.cite web | title = Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10161| accessdate = ]

Role In Hair Growth/Loss

In February 2008 researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that the gene P2RY5 causes a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss. [http://www.breitbart.com/article.php?id=080224183501.59dd4jek&show_article=1] [http://www.msnbc.msn.com/id/23334554/]

ee also

* P2Y receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ralevic V, Burnstock G |title=Receptors for purines and pyrimidines. |journal=Pharmacol. Rev. |volume=50 |issue= 3 |pages= 413–92 |year= 1998 |pmid= 9755289 |doi=
*cite journal | author=Toguchida J, McGee TL, Paterson JC, "et al." |title=Complete genomic sequence of the human retinoblastoma susceptibility gene. |journal=Genomics |volume=17 |issue= 3 |pages= 535–43 |year= 1993 |pmid= 7902321 |doi= 10.1006/geno.1993.1368
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Herzog H, Darby K, Hort YJ, Shine J |title=Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. |journal=Genome Res. |volume=6 |issue= 9 |pages= 858–61 |year= 1997 |pmid= 8889552 |doi=
*cite journal | author=Li Q, Schachter JB, Harden TK, Nicholas RA |title=The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 455–60 |year= 1997 |pmid= 9240460 |doi= 10.1006/bbrc.1997.6984
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Adrian K, Bernhard MK, Breitinger HG, Ogilvie A |title=Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 127–38 |year= 2000 |pmid= 11004484 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ihara H, Hirukawa K, Goto S, Togari A |title=ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. |journal=Biochem. Biophys. Res. Commun. |volume=326 |issue= 2 |pages= 329–34 |year= 2005 |pmid= 15582581 |doi= 10.1016/j.bbrc.2004.11.037

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