Product inhibition

Product inhibition

Product inhibition is a type of enzyme inhibition where the product of a enzyme reaction binds to the enzyme and inhibits its activity. [cite journal |author=Walter C, Frieden E. |title=The prevalence and significance of the product inhibition of enzymes |journal=Adv. Enzymol. Relat. Areas Mol. Biol. |volume=25 |issue= |pages=167–274 |year=1963 |pmid=14149677 |doi=10.1002/9780470122709.ch4]

This can be important in the regulation of metabolism as a form of negative feedback controlling metabolic pathways. [cite journal |author=Hutson NJ, Kerbey AL, Randle PJ, Sugden PH |title=Regulation of pyruvate dehydrogenase by insulin action |journal=Prog. Clin. Biol. Res. |volume=31 |issue= |pages=707–19 |year=1979 |pmid=231784] Product inhibition is also an important topic in biotechnology as overcoming this effect can increase the yield of a product such as an antibiotic. [cite journal |author=Schügerl K, Hubbuch J |title=Integrated bioprocesses |journal=Curr. Opin. Microbiol. |volume=8 |issue=3 |pages=294–300 |year=2005 |pmid=15939352 |doi=10.1016/j.mib.2005.01.002]

References


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  • end product inhibition — end product inhibition. См. ретроингибирование. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • end-product inhibition — The inhibition of an enzyme by a metabolite. Typically, the enzyme is the first enzyme in a biosynthetic pathway, and the metabolite the product of the last step in the pathway. See: feedback inhibition …   Glossary of Biotechnology

  • end product inhibition — See feedback inhibition …   Dictionary of microbiology

  • inhibition — /in i bish euhn, in hi /, n. 1. the act of inhibiting. 2. the state of being inhibited. 3. something that inhibits; constraint. 4. Psychol. a. the blocking or holding back of one psychological process by another. b. inappropriate conscious or… …   Universalium

  • inhibition — 1. Depression or arrest of a function. SEE ALSO: inhibitor. 2. In psychoanalysis, the restraining of instinctual or unconscious drives or tendencies, especially if they conflict with one s conscience or with societal demands. 3. In psychology, a… …   Medical dictionary

  • feedback inhibition — The process by which the accumulated end product of a biochemical pathway stops synthesis of that product. The effect is that a late metabolite of a synthetic pathway regulates the synthesis of an earlier step of the pathway. See: end product… …   Glossary of Biotechnology

  • feedback inhibition — feedback inhibition. = end product inhibition (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • uncompetitive inhibition — inhibition of an enzyme by a substance that binds reversibly to the enzyme substrate complex. The enzyme substrate inhibitor complex cannot yield the normal product until the inhibitor is released …   Medical dictionary

  • Non-competitive inhibition — is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme, by binding not to the active site on the enzyme, but to a different site.[1] More specifically, it is a special instance of mixed inhibition where the… …   Wikipedia

  • feedback inhibition — Suppression of the activity of an enzyme by a product of the sequence of reactions in which the enzyme is participating. When the product accumulates in a cell beyond an optimal amount, it decreases its own production by inhibiting an enzyme… …   Universalium

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