Phosphopyruvate hydratase

In enzymology, a phosphopyruvate hydratase (EC number|4.2.1.11) is an enzyme that catalyzes the chemical reaction

:2-phospho-D-glycerate $ightleftharpoons$ phosphoenolpyruvate + H₂O

Hence, this enzyme has one substrate, 2-phospho-D-glycerate, and two products, phosphoenolpyruvate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). Other names in common use include enolase, 2-phosphoglycerate dehydratase, 14-3-2-protein, nervous-system specific enolase, phosphoenolpyruvate hydratase, 2-phosphoglycerate dehydratase, 2-phosphoglyceric dehydratase, 2-phosphoglycerate enolase, gamma-enolase, and 2-phospho-D-glycerate hydro-lyase. This enzyme participates in glycolysis / gluconeogenesis. At least one compound, Phosphonoacetohydroxamate is known to inhibit this enzyme. The human gene that makes this enzyme is ENO2.

tructural studies

As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E9I, PDB link|1EBG, PDB link|1EBH, PDB link|1ELS, PDB link|1IYX, PDB link|1L8P, PDB link|1NEL, PDB link|1OEP, PDB link|1ONE, PDB link|1P43, PDB link|1P48, PDB link|1PDY, PDB link|1PDZ, PDB link|1TE6, PDB link|1W6T, PDB link|2AKM, PDB link|2AKZ, PDB link|2AL1, PDB link|2AL2, PDB link|2FYM, PDB link|2ONE, PDB link|2PA6, PDB link|3ENL, PDB link|4ENL, PDB link|5ENL, PDB link|6ENL, and PDB link|7ENL.

References

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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 471-494.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9014-08-8."

Gene Ontology (GO) codes