Dimethylmaleate hydratase

Dimethylmaleate hydratase
dimethylmaleate hydratase
Identifiers
EC number 4.2.1.85
CAS number 93229-56-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dimethylmaleate hydratase (EC 4.2.1.85) is an enzyme that catalyzes the chemical reaction

(2R,3S)-2,3-dimethylmalate \rightleftharpoons dimethylmaleate + H2O

Hence, this enzyme has one substrate, (2R,3S)-2,3-dimethylmalate, and two products, dimethylmaleate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming). This enzyme is also called (2R,3S)-2,3-dimethylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, iron.

References

  • Kollmann-Koch A, Eggerer H (1984). "Nicotinic acid metabolism. Dimethylmaleate hydratase". Hoppe. Seylers. Z. Physiol. Chem. 365 (8): 847–57. doi:10.1515/bchm2.1984.365.2.847. PMID 6489933. 
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