GISSI

The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) (Italian group for the study of the survival of Myocardial Infarction) is an influential cardiology research group founded as a collaboration between two Italian organisations – the Mario Negri Institute and the Associazione Nazionale dei Medici Cardiologi Ospedalieri (ANMCO). [http://www.gissi.org/EngIntro/T_Intro_ENG.php GISSI > Presentation > Presentation ] ] The trials carried out by GISSI have "obtained wide recognition in the international world of cardiology and are considered a methodological landmark". Four large-scale clinical trials over the past 20 years (GISSI 1 [cite journal |author= |title=Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) |journal=Lancet |volume=1 |issue=8478 |pages=397–402 |year=1986 |pmid=2868337 |doi=] [cite journal |author= |title=Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Gruppo Italiano per lo Studio della Streptochi-nasi nell'Infarto Miocardico (GISSI) |journal=Lancet |volume=2 |issue=8564 |pages=871–4 |year=1987 |pmid=2889079 |doi=] , GISSI 2 [cite journal |author= |title=GISSI-2: a factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12,490 patients with acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico |journal=Lancet |volume=336 |issue=8707 |pages=65–71 |year=1990 |pmid=1975321 |doi=] [cite journal |author= |title=In-hospital mortality and clinical course of 20,891 patients with suspected acute myocardial infarction randomised between alteplase and streptokinase with or without heparin. The International Study Group |journal=Lancet |volume=336 |issue=8707 |pages=71–5 |year=1990 |pmid=1975322 |doi=] , GISSI 3 [cite journal |author= |title=GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico |journal=Lancet |volume=343 |issue=8906 |pages=1115–22 |year=1994 |pmid=7910229 |doi=] , GISSI Prevention [cite journal |author= |title=Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico |journal=Lancet |volume=354 |issue=9177 |pages=447–55 |year=1999 |pmid=10465168 |doi=] ) have involved more than 60,000 patients with acute myocardial infarction (AMI).

References

Further reading

* [http://www.olivehealth.com/articles/olive-oil-health-effects/olive-oil-and-heart-disease.html Article on olive oil and heart disease] - mentions the GISSI Prevention study