DEFB4

Defensin, beta 4, also known as DEFB4, is a human gene.

PBB_Summary
section_title =
summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [cite web | title = Entrez Gene: DEFB4 defensin, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1673| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Weinberg A, Krisanaprakornkit S, Dale BA |title=Epithelial antimicrobial peptides: review and significance for oral applications. |journal=Crit. Rev. Oral Biol. Med. |volume=9 |issue= 4 |pages= 399–414 |year= 1999 |pmid= 9825219 |doi=
*cite journal | author=Schröder JM, Harder J |title=Human beta-defensin-2. |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 6 |pages= 645–51 |year= 1999 |pmid= 10404637 |doi=
*cite journal | author=Harder J, Bartels J, Christophers E, Schröder JM |title=A peptide antibiotic from human skin. |journal=Nature |volume=387 |issue= 6636 |pages= 861 |year= 1997 |pmid= 9202117 |doi= 10.1038/43088
*cite journal | author=Bals R, Wang X, Wu Z, "et al." |title=Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. |journal=J. Clin. Invest. |volume=102 |issue= 5 |pages= 874–80 |year= 1998 |pmid= 9727055 |doi=
*cite journal | author=Liu L, Wang L, Jia HP, "et al." |title=Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. |journal=Gene |volume=222 |issue= 2 |pages= 237–44 |year= 1999 |pmid= 9831658 |doi=
*cite journal | author=Mathews M, Jia HP, Guthmiller JM, "et al." |title=Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. |journal=Infect. Immun. |volume=67 |issue= 6 |pages= 2740–5 |year= 1999 |pmid= 10338476 |doi=
*cite journal | author=Jia HP, Mills JN, Barahmand-Pour F, "et al." |title=Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. |journal=Infect. Immun. |volume=67 |issue= 9 |pages= 4827–33 |year= 1999 |pmid= 10456937 |doi=
*cite journal | author=Yang D, Chertov O, Bykovskaia SN, "et al." |title=Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. |journal=Science |volume=286 |issue= 5439 |pages= 525–8 |year= 1999 |pmid= 10521347 |doi=
*cite journal | author=Diamond G, Kaiser V, Rhodes J, "et al." |title=Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. |journal=Infect. Immun. |volume=68 |issue= 1 |pages= 113–9 |year= 2000 |pmid= 10603376 |doi=
*cite journal | author=Harder J, Meyer-Hoffert U, Teran LM, "et al." |title=Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. |journal=Am. J. Respir. Cell Mol. Biol. |volume=22 |issue= 6 |pages= 714–21 |year= 2000 |pmid= 10837369 |doi=
*cite journal | author=Hoover DM, Rajashankar KR, Blumenthal R, "et al." |title=The structure of human beta-defensin-2 shows evidence of higher order oligomerization. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32911–8 |year= 2000 |pmid= 10906336 |doi= 10.1074/jbc.M006098200
*cite journal | author=Meyer JE, Harder J, Görögh T, "et al." |title= [hBD-2 gene expression in nasal mucosa] |journal=Laryngorhinootologie |volume=79 |issue= 7 |pages= 400–3 |year= 2000 |pmid= 11005092 |doi=
*cite journal | author=Ali RS, Falconer A, Ikram M, "et al." |title=Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. |journal=J. Invest. Dermatol. |volume=117 |issue= 1 |pages= 106–11 |year= 2001 |pmid= 11442756 |doi= 10.1046/j.0022-202x.2001.01401.x
*cite journal | author=Carothers DG, Graham SM, Jia HP, "et al." |title=Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa. |journal=American journal of rhinology |volume=15 |issue= 3 |pages= 175–9 |year= 2001 |pmid= 11453504 |doi=
*cite journal | author=Biragyn A, Surenhu M, Yang D, "et al." |title=Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6644–53 |year= 2002 |pmid= 11714836 |doi=
*cite journal | author=Bauer F, Schweimer K, Klüver E, "et al." |title=Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. |journal=Protein Sci. |volume=10 |issue= 12 |pages= 2470–9 |year= 2002 |pmid= 11714914 |doi=
*cite journal | author=Takahashi A, Wada A, Ogushi K, "et al." |title=Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein. |journal=FEBS Lett. |volume=508 |issue= 3 |pages= 484–8 |year= 2001 |pmid= 11728477 |doi=
*cite journal | author=Schibli DJ, Hunter HN, Aseyev V, "et al." |title=The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8279–89 |year= 2002 |pmid= 11741980 |doi= 10.1074/jbc.M108830200

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