Phenylacetate-CoA ligase

In enzymology, a phenylacetate-CoA ligase is an enzyme that catalyzes the chemical reaction

:ATP + phenylacetate + CoA $ightleftharpoons$ AMP + diphosphate + phenylacetyl-CoA

The 3 substrates of this enzyme are ATP, phenylacetate, and CoA, whereas its 3 products are AMP, diphosphate, and phenylacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is phenylacetate:CoA ligase (AMP-forming). Other names in common use include phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

The EC number for this enzyme class is 6.2.1.30 and its CAS registry number is CAS registry|57219-71-3.

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Gene Ontology (GO) codes