Glutathionylspermidine synthase

In enzymology, a glutathionylspermidine synthase (EC number|6.3.1.8) is an enzyme that catalyzes the chemical reaction

:glutathione + spermidine + ATP $ightleftharpoons$ glutathionylspermidine + ADP + phosphate

The 3 substrates of this enzyme are glutathione, spermidine, and ATP, whereas its 3 products are glutathionylspermidine, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule] . This enzyme is also called glutathione:spermidine ligase (ADP-forming). This enzyme participates in glutathione metabolism. It employs one cofactor, magnesium.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2IO7, PDB link|2IO8, PDB link|2IO9, PDB link|2IOA, and PDB link|2IOB.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9077-09-2."

Gene Ontology (GO) codes