Formate-tetrahydrofolate ligase

In enzymology, a formate-tetrahydrofolate ligase (EC number|6.3.4.3) is an enzyme that catalyzes the chemical reaction

:ATP + formate + tetrahydrofolate $ightleftharpoons$ ADP + phosphate + 10-formyltetrahydrofolate

The 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:tetrahydrofolate ligase (ADP-forming). Other names in common use include formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, and tetrahydrofolate formylase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EG7, PDB link|1FP7, and PDB link|1FPM.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-66-9."

Gene Ontology (GO) codes