Formate-dihydrofolate ligase

In enzymology, a formate-dihydrofolate ligase (EC number|6.3.4.17) is an enzyme that catalyzes the chemical reaction

:ATP + formate + dihydrofolate $ightleftharpoons$ ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming). Other names in common use include formyltransferase, dihydrofolate, dihydrofolate formyltransferase, and formyl dihydrofolate synthase.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|123303-25-3."

Gene Ontology (GO) codes