Indole-3-glycerol-phosphate synthase
- Indole-3-glycerol-phosphate synthase
In enzymology, an indole-3-glycerol-phosphate synthase (EC number|4.1.1.48) is an enzyme that catalyzes the chemical reaction
:1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O
Hence, this enzyme has one substrate, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate, but 3 products: 1-C-(indol-3-yl)-glycerol 3-phosphate, CO2, and H2O.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing 1-C-(indol-3-yl)glycerol-3-phosphate-forming] . Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, and carboxy-lyase (cyclizing). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general. It employs one cofactor, pyruvate.
tructural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A53, PDB link|1I4N, PDB link|1J5T, PDB link|1JCM, PDB link|1JUK, PDB link|1JUL, PDB link|1LBF, PDB link|1LBL, PDB link|1PII, PDB link|1VC4, and PDB link|2C3Z.
References
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|9031-60-1."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
Indole-3-glycerol-phosphate lyase — In enzymology, an indole 3 glycerol phosphate lyase (EC number|4.1.2.8) is an enzyme that catalyzes the chemical reaction:(1S,2R) 1 C (indol 3 yl)glycerol 3 phosphate ightleftharpoons indole + D glyceraldehyde 3 phosphateHence, this enzyme has… … Wikipedia
Tryptophane synthase — Structure de la tryptophane synthase. La sous unité α est en bleu et la sous unité β est en vert … Wikipédia en Français
List of EC numbers (EC 4) — This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 4.1: Carbon Carbon LyasesEC… … Wikipedia
tryptophan — 2 Amino 3 (3 indolyl)propionic acid; the l isomer is a component of proteins; a nutritionally essential amino acid. t. decarboxylase SYN: aromatic d amino acid decarboxylase. t. desmolase SYN: t. synthase. t. 2,3 dioxygenase an oxidoreductase… … Medical dictionary
Tryptophane — L ou S( ) tryptophane D ou R(+) tryptophane … Wikipédia en Français
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia
