- Diphosphomevalonate decarboxylase
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diphosphomevalonate decarboxylase Identifiers EC number 4.1.1.33 CAS number 9024-66-2 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a diphosphomevalonate decarboxylase (EC 4.1.1.33) is an enzyme that catalyzes the chemical reaction
- ATP + (R)-5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
Thus, the two substrates of this enzyme are ATP and (R)-5-diphosphomevalonate, whereas its 4 products are ADP, phosphate, isopentenyl diphosphate, and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP isopentenyl-diphosphate-forming). Other names in common use include pyrophosphomevalonate decarboxylase, mevalonate-5-pyrophosphate decarboxylase, pyrophosphomevalonic acid decarboxylase, 5-pyrophosphomevalonate decarboxylase, mevalonate 5-diphosphate decarboxylase, and ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating). This enzyme participates in biosynthesis of steroids.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1FI4, 2HK2, 2HK3, and 2HKE.
References
- Bloch K, Chaykin S, Phillips AH and de Waard A (1959). "Mevalonic acid pyrophosphate and isopentenyl pyrophosphate". J. Biol. Chem. 234: 2595–2604.
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