Diphosphomevalonate decarboxylase

Diphosphomevalonate decarboxylase
diphosphomevalonate decarboxylase
Identifiers
EC number 4.1.1.33
CAS number 9024-66-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diphosphomevalonate decarboxylase (EC 4.1.1.33) is an enzyme that catalyzes the chemical reaction

ATP + (R)-5-diphosphomevalonate \rightleftharpoons ADP + phosphate + isopentenyl diphosphate + CO2

Thus, the two substrates of this enzyme are ATP and (R)-5-diphosphomevalonate, whereas its 4 products are ADP, phosphate, isopentenyl diphosphate, and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP isopentenyl-diphosphate-forming). Other names in common use include pyrophosphomevalonate decarboxylase, mevalonate-5-pyrophosphate decarboxylase, pyrophosphomevalonic acid decarboxylase, 5-pyrophosphomevalonate decarboxylase, mevalonate 5-diphosphate decarboxylase, and ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating). This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1FI4, 2HK2, 2HK3, and 2HKE.

References

  • Bloch K, Chaykin S, Phillips AH and de Waard A (1959). "Mevalonic acid pyrophosphate and isopentenyl pyrophosphate". J. Biol. Chem. 234: 2595–2604. 
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