Haloalkane dehalogenase

In enzymology, a haloalkane dehalogenase (EC number|3.8.1.5) is an enzyme that catalyzes the chemical reaction

:1-haloalkane + H₂O $ightleftharpoons$ a primary alcohol + halide

Thus, the two substrates of this enzyme are 1-haloalkane and H₂O, whereas its two products are primary alcohol and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 1-haloalkane halidohydrolase. Other names in common use include 1-chlorohexane halidohydrolase, and 1-haloalkane dehalogenase. Haloalkane dehalogenases are found in certain bacteria and belong the the alpha-beta hydrolase fold superfamily of enzymes. They participate in several metabolic pathways: 1,2-dichloroethane degradation, 1-chloro-n-butane degradation, hexachlorocyclohexane degradation, 1,2-dibromoethane degradation, 2-chloroethyl-vinylether degradation, and 1,3-dichloropropene degradation.

tructural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B6G, PDB link|1BE0, PDB link|1BEE, PDB link|1BEZ, PDB link|1BN6, PDB link|1BN7, PDB link|1CIJ, PDB link|1CQW, PDB link|1CV2, PDB link|1D07, PDB link|1EDB, PDB link|1EDD, PDB link|1EDE, PDB link|1HDE, PDB link|1K5P, PDB link|1K63, PDB link|1K6E, PDB link|1MJ5, PDB link|2DHC, PDB link|2DHD, PDB link|2DHE, PDB link|2EDA, PDB link|2EDC, PDB link|2PKY, and PDB link|2YXP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|95990-29-7."

Gene Ontology (GO) codes